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Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life - PMC

The exact mechanism remains a subject of intense research, but it may involve indirect effects on NOS enzyme expression or activity, or interaction with downstream effectors of NO signaling like soluble guanylate cyclase (sGC)

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Meanwhile, the JAK-STAT-driven inflammatory mediators IL-6 and IFN-γ upregulate hepcidin, suppressing iron export and causing intracellular iron accumulation