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The core functions of astrocytes include controlling the homeostasis of neurotransmitters (through uptake, catabolism and the supply of precursors), K + buffering, metabolic support, scavenging of reactive oxygen species (ROS), regulation of water transport and interstitial fluid, formation—through perivascular endfeet—of the parenchymal component of the blood–brain barrier (glia limitans perivascularis), contribution to chemosensing, regulation of energy homeostasis, participation in transmitophagy, and many other processes 14

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Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease