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Vitamin B12 deficiency can cause symptoms like headaches, fatigue, depressive mood, gastrointestinal issues, and more. While vegetarians are at a higher risk of vitamin B12 deficiency, it can affect non-vegetarians too. Check

Interestingly, compound 1 is destroyed by ascorbate oxidase (a prominent cell wall localised enzyme) so may have an ene diol group [96]

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In modern biochemistry these are referred to as reactive O2 species