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However, it is unclear whether decreased GSH levels only occurs downstream of the EGFRm/T790M or if this is a common feature of other erlotinib resistance pathways such as c-Met amplification

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Infection with Hepatitis B virus (HBV) and Hepatitis C virus (HCV) is a known risk factor for HCC and the major contributor to the progression of chronic viral hepatitis to liver fibrosis/cirrhosis, ultimately leading to HCC (Thomas, 2019)