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[162], reported significant reductions in plasma total homocysteine in 15 healthy participants who administered six grams of anhydrous betaine daily for three weeks

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One possibility is that changes in miR203-5p (and/or other miRNA molecules not examined in the present study) lead to transcriptional changes, potentially through other epigenetic mechanisms such as histone methylation/acetylation and heterochromatin modifications, that escalate over time and result in impaired glutamate homeostasis and glutamate-GABA communication