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CD38, a transmembrane glycoprotein that lacks an internal signaling domain, is a surface molecule expressed by normal T, B, NK and myeloid populations as well as by different tumor cells ( + levels inside the BM niche where the mPC grows ( + to cyclic adenosine diphosphate ribose (cADPR) via cyclase activity and cADPR to ADPR via hydrolase activity (Figure 1)

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Intracellular NAD⁺-related research mechanisms