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It will be important to test the effects of NAD + boosters in gold-standard cancer models, either in the absence of, or combination with, standard chemotherapeutic agents

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Considering that primary MET genomic amplification a low-frequency event in most tumors, the researchers developed an antibody–drug conjugate, telisotuzumab–vedotin, also known as ABBV-399, which is composed of telisotuzumab and cytotoxic monomethyl auristatin E (MMAE) via a valine–citrulline linker (Wang et al., 2017)