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In the basal state, ABHD5 is bound to PLIN1 (14, 37), which upon hormonal stimulation (described in detail below) releases ABHD5 to interact with PNPLA2 (Figure 1)

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There is a body of evidence indicating that a lack of RIPK3 and MLKL expression can reduce kidney damage due to IRI, and the necroinflammation driven by RIPK3/MLKL-dependent necroptosis may lead to the progression of IRI to CKD [29]