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After binding to its cell membrane receptor, TNFα activates NF-κB in the following sequence: (a) phosphorylation of the inhibitor of NF-κB (IκB-α) by IKK

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Findings demonstrated that apelin-13 enhanced the activity of antioxidant enzymes such as SOD, CAT, and GSH-Px while lowering the levels of MDA and total oxidant capacity, thus exhibiting significant antioxidant properties