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Caffeine can also inhibit phosphodiesterase and suppresses the negative effects of adenosine on noradrenaline release, thus can induce fat oxidation (Reference Dulloo, Seydoux and Girardier7)

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On the other hand, selenium transport protein (selenoprotein P) and Sepp1 expressed by neurons of the substantia nigra of the midbrain indicate a role for Sepp1 in the nigrostriatal pathway, which suggests that local release of Sepp1 in the striatum may be important for signaling and/or synthesis of other selenoproteins with neuroprotective activity [32]