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Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives | Molecular and Cellular Biochemistry | Springer Nature Link

The aim of Cheng et al

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Systemically, two things do look dose- and frequency-related in the reports: acneiform eruptions (weekly high-dose regimens dominate the case literature) and, anecdotally, insomnia and jitteriness in the day or two after frequent large doses

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