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In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450’s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]

The resin consists of reduced glutathione (GSH) covalently coupled to 6% cross