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These include- Aged over 75 Decreased stomach acid Frequent use of antacids Autoimmune conditions affecting the stomach High doses of folic acid Stomach surgery Prolonged use of metformin Adoption of a vegan or vegetarian diet Excessive alcohol consumption How Does Vitamin B12 Benefit Your Body

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12,53,57 Table 2 shows the prevalence of DPYD variant carriers identified in the included studies (Appendix 5)