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DIDO (Death inducer obliterator) and PHF3 (PHD finger protein 3) share a different domain architecture comprising a PHD (Plant homeodomain), a TLD (TFIIS-like domain) and the SPOC domain

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Why You Need Both for Cellular Protection The synergy operates bidirectionally—glutathione protects NAD+ by reducing oxidative DNA damage, which limits activation of PARP enzymes that are major consumers of NAD+