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(full study link in comments below) Also, this paragraph from #Katzungs_basic_and_clinical_pharmacology, 16th edition (2023), page 798: (the paragraph's picture is in comments) [[[[ Metformin interferes with the calcium-dependent absorption of vitamin B12-intrinsic factor complex in the terminal ileum, and vitamin B12 deficiency can occur after many years of metformin use

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10.1016/j.freeradbiomed.2017.10.345 126 WangN.ZengG.-Z.YinJ.-L.BianZ.-X