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Supplementing with B12 Vitamin B12, bound to protein in food, is released by the activity of hydrochloric acid and gastric protease in the stomach

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SLC7A11 (also known as xCT) associates with SLC3A2 (CD98) at the plasma membrane and serves as the primary transporter of cystine, the oxidized form of cysteine and predominant cysteine species in both plasma and cell culture media, whereas reduced cysteine is transported through neutral amino acid systems (Figure 5A) (Bannai & Kitamura, 1980)