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While isolated changes in coagulation parameters, such as elevation in D-dimer, increase in fibrinogen degradation product, decrease of fibrinogen levels and prolongation of activated partial thromboplastin time (aPTT), can be observed in a high proportion of patients (215, 216), the analytical and clinical phenotype of DIC occurs only in cases of high-grade toxicities and is related to an increase of the non-relapse mortality (215)

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Tauris, London 2010