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The overexpression of arginine methyltransferase 5 (PRMT5) in solid and hematological tumors leads to the elevation of the methylation level of arginine residues on functionally related proteins in tumor cells, which affects cell cycle regulation, mRNA splicing, cell differentiation, signal transduction, and other physiological processes

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The result provides a receptor-level basis for classifying cagrilintide as a long-acting amylin analogue and for investigating signaling across more than one receptor configuration rather than treating the compound as a single-target ligand