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In fact, it was demonstrated that only PLD2-activating opioids (like DAMGO, β -endorphin, methadone, piritramide, fentanyl, sufentanil, and etonitazene) strongly induce MOR endocytosis, whereas agonists that do not activate PLD2 (like morphine, buprenorphine, hydromorphone, and oxycodone) failed to activate MOR internalization (Koch et al., 2009)

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