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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinflammatory secretome known as the senescence-associated secretory phenotype (SASP)” (FYI = chrondocytes are cells found in healthy cartilage tissue) The good news is that FOXO4-DRI could be a useful secondary tool in improving the outcome of ACI: “Results showed that the treatment of FOXO4-DRI removed more than half of the cells in [population doubling level] PDL9 but did not significantly affect the cell number of PDL3 chondrocytes

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doi: 10.1371/journal.pone.0113486