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Many treatment modalities have been developed to restore the immune tolerance and immmunoregulatory balance in autoimmune rheumatic diseases, including the use of peptide-based therapeutics or the use of nanoparticles-based nanotechnology

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The guideline notes that evidence comparing methenamine to antibiotic prophylaxis is of low strength, but some studies show no significant difference in efficacy between methenamine and antibiotics for UTI prevention