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Rat blood serum samples were pre-equilibrated at 37°C and then 10 μ l (50 μ g) of each drug solution was added to 90 μ l of rat serum in a 1 activity relationship (QSAR) modeling estimates generated by the ADMET Predictor (Simulations Plus, Inc

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Therefore, we may generate the hypothesis that amino acids affect the neurovascular functions first, by inducing the release of nitric oxide and vasodilation-related neuropeptides, which may further aggravate inflammatory reaction if stimulated by other factors