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This review elucidates the regulatory mechanisms of various PCD pathways in EMs and their interactions with key signaling cascades, including PI3K/Akt/mTOR, MAPK, NF-κB, and Bcl-2

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GSH dynamics in endoplasmic reticulum Similar to mitochondria, the ER relies on cytosolic GSH as it lacks GSH synthesis machinery [10,50]