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The combined biochemical alterations, which include lactic acidosis, elevated levels of Krebs cycle metabolites, low plasma carnitine, as well as impaired glucose uptake by the brain, and low adenosine triphosphate levels, are all linked to autism, and these findings indicate the role of a biochemical link between ASD and metabolic alterations induced by mitochondrial dysfunction [68]

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Thus, researchers have investigated the use of growth factors to increase cell recruitment, improve cell chondrogenesis, and optimize chondrocyte populations for cartilage regeneration therapies