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Despite not causing any physical pain, vitiligo can originate several psychosocial disorders, drastically reducing patients’ quality of life

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Enhanced Serotonin Synthesis Pathway: Tryptophan ↓ (requires folate + B12 for methylation) 5-Hydroxytryptophan (5-HTP) ↓ Serotonin B12’s Role: Supports enzymatic conversion Provides methyl groups via SAMe Optimizes tryptophan hydroxylase activity Clinical Effect: More serotonin is available for SSRIs to work with Enhanced synaptic serotonin levels Better antidepressant response 2