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Upon entering the cell, RSV activates SIRT1, leading to the inhibition of RelA acetylation, and stimulates inhibitor protein-B (IkB) degradation, which in turn reduces NF-kB-induced TNF-α, IL-1, IL-6, matrix metalloproteinase (MMP) and COX-2 production [77]

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They have examined this in DRG explants and have utilized a variety of different inhibitors (as well as Bax and p75 KO neurons) to study the mechanism of axonal degeneration of these two distinct populations of neurons