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On the other hand, it is well-known that glutathione deficiency contributes to the oxidative stress, and has an important role in aging, as well as in the pathogenesis of different cardiovascular diseases

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It is possible that Keap1 activity is slightly impaired under basal conditions, by ROS and thiol-reactive endogenous electrophilic metabolites (e.g., acrolein, 15-deoxy-Δ 1214 -prostaglandin J 2 , dopa- O -quinone, fumarate, 4-hydroxynonenal, and maleylacetoacetate), as well as by dietary factors