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Creatine deficiency has also been associated with epilepsy and aphasia (difficulty reading, speaking and writing - a common problem in children with autism) (Perna etal, 2016), and with mental retardation, autism, hypotonia, and seizures (Longo etal, 2011)

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For instance, many adaptogenic herbs and nutrients that were once thought to function primarily by supporting adrenal function have been shown to have mechanism that modulate non-adrenal HPA axis or glucocorticoid signaling functions

Mechanisms of action and clinical effects