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As a key cell signaling molecule, CO not only regulates vascular tone but also confers resistance to ER stress in endothelial cells by down-regulating CCAAT/enhancer-binding protein homologous protein expression and up-regulating the Nrf2/HO-1 pathway (Yang et al., 2014)
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In addition, high level of LDL-C can cause ectopic lipid deposition and associated metabolic diseases, such as non-alcoholic fatty liver disease ( Gut microbiota regulates several diseases, including liver diseases ( Microbial effects on cholesterol metabolism Gut microbiota, which is influenced by diet and living environment, is individually unique and highly related to cholesterol metabolism ( The SCFAs, BAs, TMAO, and LPS are major gut microbiota metabolites that broadly affect the human cholesterol metabolism
