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This methodological approach aims to test, at both structural and functional levels, the hypothesis’s dimension of “early erythrophagocytosis and immune modulation.” 5.1.6 Validation with ex vivo patient samples In erythrocytes obtained from cancer patients and healthy controls, ATP, NADPH/NADP + , NADH/NAD + , 2,3-BPG levels, metHb percentage, proportion of PS-positive cells, membrane potential (RMP), deformability, and ion contents should be measured