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This "reward normalization" hypothesis is supported by preclinical data showing that GLP-1R agonists restore dopamine D2 receptor expression in the striatum of obese animals and reduce conditioned place preference for multiple rewarding stimuli (food, alcohol, cocaine) through the same mechanism

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Similarly, thiazoloquin(az)olin(on)e compounds, 78c, have been demonstrated to be highly potent and specific CD38 inhibitors with improved contractile function, coronary flow, and decreased infarction against I/R injury [27]