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In contrast, ALKBH5, a nuclear protein that binds single-stranded nucleotides, catalyzes m6A demethylation by directly removing methyl groups from methylated adenosine in m6A, unlike FTO, which operates through an oxidative process [28]

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SAM acts as a methyl donor and, after the transmethylation reaction, is converted into S-adenosylhomocysteine (SAH), as discussed in Section 2.1

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