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This limitation reflects a broader gap in the field: most randomized controlled trials and systematic reviews focus on major depressive disorder or depressive symptoms in heterogeneous populations, without separate analyses for distinct presentations like vascular depression, treatment-associated depressive states, or mood disturbances in the context of specific medical conditions

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Lipoic acid is an endogenously produced antioxidant with multiple biologic functions including free-radical scavenging, metallic ion chelation, regeneration of intracellular glutathione, and oxidative damage repair of macromolecules