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Therefore, the cytoplasmic-free zinc concentration has to be tightly regulated [98] and is buffered to a picomolar level [97], being either transported out of the cell and sequestered into vesicles via ZIP and ZnT transporters, or bound to proteins such as metallothioneins (MTs) [99] (Figure 2A,B)

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In host amphibian cells, Bd infection decreased intracellular glutathione content and increased reactive oxygen species, suggesting that chytridiomycosis pathogenesis may involve oxidative stress