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First-pass metabolism The metabolism of orally ingested compounds before reaching general circulation

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Viruses, such as HIV, Epstein–Barr virus, human cytomegalovirus (HCMV) and adenoviruses (AdVs) may cause increase nutrient uptake by host cells by interacting with cell surface receptors and activating signalling pathways and metabolic-regulating transcription factors that coordinate expression of nutrient transporters 12,28,29