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These strategies include the exhaustion of mutant p53 via the application of histone deacetylase (HDAC) inhibitors and heat shock protein 90 (HSP90) inhibitors to suppress tumor cell growth, blocking growth signals regulated by mutated p53

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In mice overexpressing the insulin receptor in skeletal muscle (Supplemental Figure 6B) (45), transcriptomic profiling of muscle revealed a significant downregulation of Chac1 (Figure 6B and Supplemental Figure 6C)

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