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Insulin and IGF-1 signaling and longevity in invertebrates The IIS system is an ancient system that is highly conserved and coordinates growth, differentiation and metabolism in response to changing environmental conditions and nutrient availability (see Figure 1) [1]

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It will be argued that the inherent versatility of LC methods makes it eminently suitable to tackle questions regarding the exposure-response relationship of other emerging TMS to more effectively deal with this emerging public health crisis