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Post-exertional malaise after Lyme disease: a soldier’s case Post-exertional malaise can limit physical and cognitive activity The symptom is associated with ME/CFS and may follow Lyme disease A soldier’s case illustrates the challenges of diagnosis and recovery Post-exertional malaise (PEM) is a worsening of symptoms following physical, cognitive, or emotional exertion and is one of the defining features of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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