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Rev Neurosci (2015) 26(1):49–73.10.1515/revneuro-2014-0060 47 LiuPFleeteMSJingYCollieNDCurtisMAWaldvogelHJet alAltered arginine metabolism in Alzheimer’s disease brains

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To avoid this, under second aspect, the invention provides a sustained release or controlled release transdermal delivery systems