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First you will see a report from 1971 that in a study on excessive prescribing, B12 treatment was singled out, possibly due to the idea that GP’s were giving patients B12 injections, willy nilly as a ‘tonic’

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Methysticin is thought to help in the neuroprotection against ischemia and, in combination with dihydromethysticin, may reduce brain infarction in mice [19]