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Oxidative stress is characterized by excess reactive oxygen species that overwhelm endogenous antioxidant defenses and significantly contribute to endothelial dysfunction in ED [9]

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Because of the need for frequent dosing (0.2 to 0.4 mg/kg subcutaneously every 8 hours) and the risk of hypotension and sedation, the clinical use of phenothiazine antiemetics is limited to hospitalized patients with refractory vomiting and should be avoided in patients who are dehydrated or hypotensive