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The most important are the 78 kDa glucose regulatory protein (GRP78) and protein disulfide isomerase (PDI)

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It has been previously reported that GSK 3β inhibitors (SB-216763 and AR-A014418) significantly suppress the growth of patient-derived xenograft (PDX) colon cancer, and GSK 3β inhibitors are anticipated to be therapeutic agents for colon cancer (64)