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regulate cell proliferation and apoptosis by inducing extracellular-regulated kinase 1/2 (ERK 1/2) [49], protein kinase C δ (PKCδ) [50] and mitogen-activated protein kinase (MAPK) [51]

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After thawing for 30 min at room temperature, the samples were centrifuged at 3,000 × g for 15 min at 4°C and stored at−80°C until use