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Acknowledgements We thank the staff of the clinical research section for their assistance as clinical coordinators, the staff of the Department of Molecular Imaging and Theranostics for their support with the MRI scans, the PET and the MRI operators particularly Takasama Maeda for their imaging scans, the staff of the Department of Radiopharmaceuticals Development for their radioligand synthesis, Atsuo Waki and his team for the quality assurance of the radioligands, and Takashi Horiguchi for his assistance as research administrator, Jamie Near for his assistance in MRS protocol of SPECIAL sequence