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Only BITC inhibited DMBA-induced mammary tumor development when administered to rats after a single dose of DMBA 28

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Histone methylation also exhibits decisive role: in healthy luteal cells, histone H3 trimethylation at lysine 4 (H3K4me3) is associated with active transcription and histone H3 tri-methylation at lysine 27 (H3K27me3) is associated with gene repression in luteolysis (93)