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Skeletal muscle and aging A 2019 study by Neelakantan, Brightwell, Graber, and colleagues in Biochemical Pharmacology extended the same NNMT-inhibitor chemotype (referred to in the paper as "NNMTi," a quinolinium small molecule from the 5-Amino-1MQ family, dosed at 5 and 10 mg/kg) to a different tissue context: aged skeletal muscle in 24-month-old mice

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The major issue that affects water-soluble vitamins from fat-vitamins is their sensitivity to being exposed to heat and light leading to degradation during cooking and food processing while fat soluble vitamins are relatively stable