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During energy metabolism, the mitochondria’s central role is in oxidative phosphorylation which generates ATP through processes including the TCA cycle and the electron transport chain (ETC)

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Another point of view is that H 2 S inhibits gluconeogenesis in the liver: the lack of CSE promotes gluconeogenesis in the liver, knockout CSE of HepG2 increases glucose production, while the addition of NaHS weakens the knockout effect of CSE (82)