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Moreover, urate-lowering drugs are generally safer and better tolerated than frequently used anti-inflammatory drugs such as colchicine, NSAIDs or high-dose corticosteroids, particularly so in patients with comorbidities commonly associated with gout, including chronic kidney disease, hypertension, type 2 diabetes mellitus and ischemic heart disease 37,38,39

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doi:10.1038/sj.cgt.7700775