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Preclinical work characterised AM833/Cagrilintide as a nonselective agonist at amylin receptors and the calcitonin receptor 12

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In fact, since the degradation of CRBN neo -substrates can be a major concern in the development of CRBN-based degraders 18,108–110 , a lack of independent CRBN affinity is likely a benefit that minimizes the chance of eliciting off-target neo -substrate degradation, as we see for dHTC1