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Growth hormone is a regulator of IGF-1 by controlling much of its production and release from the liver and other tissues, and thus regulating plasma concentrations of IGF-1 ( TABLE 1 Effects of reduced IIS and GH signaling on healthspan and lifespan in different taxonomic groups

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10.1016/B978-0-12-805417-8.00027-5 Prochazkova D, Bousova I, Wilhelmova N (2011) Antioxidant and prooxidant properties of flavonoids